Round Spermatid Injection (ROSI) Treatment in Saudi Arabia

Diagnosed With Severe Male Infertility? ROSI Can Help You Achieve Biological Fatherhood

For men in Saudi Arabia who’ve been told they have no mature sperm, failed multiple fertility treatments, or were unsuccessful even after Micro-TESE or ICSI, hope still exists. Introducing Round Spermatid Injection (ROSI)—a highly specialized and experimental fertility technique now offered at VIVILITY’s advanced ART centers.

This procedure is designed for the most complex cases of non-obstructive azoospermia, where mature sperm are completely absent but early-stage cells (spermatids) are still present in the testes. ROSI gives couples a real chance at biological parenthood, even when all standard options have failed.

If you’re facing a complete block in spermatogenesis, book your ROSI consultation with VIVILITY today.

What is ROSI (Round Spermatid Injection)?

ROSI (Round Spermatid Injection) is an advanced fertility technique where a round spermatid—an immature male germ cell—is isolated from testicular tissue and injected directly into the egg to achieve fertilization.

Unlike ICSI, which uses fully mature sperm, ROSI works with precursor cells that have not yet developed tails or full fertilizing capability. With the help of micromanipulation tools and a skilled embryology team, ROSI enables conception in cases where no sperm cells are found, even after testicular extraction.

This is considered a last-resort option for men with complete spermatogenic arrest, offering a new possibility for fatherhood.

Interested in exploring ROSI in KSA? Book a personalized consultation at VIVILITY today.

Who is a Candidate for ROSI in Saudi Arabia?

ROSI is a highly selective procedure, only considered after conventional sperm retrieval techniques like Micro-TESE or TESA have failed. It is ideal for:

• Men diagnosed with non-obstructive azoospermia (NOA)
• Individuals showing complete spermatogenesis failure
• Patients with maturation arrest at the round spermatid stage
• Couples who experienced failed ICSI attempts despite healthy egg quality
• Cases where no mature sperm were identified during previous surgeries or biopsies

Our specialists at VIVILITY conduct comprehensive evaluations to determine your eligibility.

Contact us today to see if you’re a ROSI candidate.

How ROSI Works – Step-by-Step Procedure at VIVILITY

ROSI requires a highly controlled laboratory environment, a specialized embryology team, and a series of advanced steps:

1. Testicular Biopsy – A small sample of tissue is extracted to search for round spermatids.
2. Spermatid Identification – Using advanced microscopy, embryologists identify round spermatids among other cells.
3. Isolation of Spermatids – The identified immature cells are separated and prepared for injection.
4. Microinjection Into Egg – A spermatid is injected directly into a mature egg retrieved from the female partner.
5. Embryo Culture – If fertilization occurs, the embryo is cultured until the blastocyst stage.
6. Embryo Transfer – A high-quality embryo is transferred into the uterus.

The entire process is performed under rigorous safety and ethical protocols in our advanced fertility labs.

Speak to our embryology experts today in KSA to discuss ROSI in detail.

ROSI vs. ICSI – What Makes It Different?

While both ROSI and ICSI are lab-assisted fertilization methods, they differ in key ways:

ROSI is not a replacement for ICSI—but it is a revolutionary solution when ICSI is no longer viable.

Considering ROSI after failed ICSI or Micro-TESE? Let our team guide you.

Success Rates and Limitations of ROSI

ROSI is still considered an experimental fertility technique, but it has shown promising results in specific cases. Success depends heavily on factors such as:

• Female partner’s egg quality and age
• Maturity of the extracted spermatids
• Embryo development potential post-injection
• Embryologist skill and lab conditions

ROSI success rates in Saudi Arabia remain modest, with fertilization rates ranging from 20% to 40% and clinical pregnancy rates between 10% to 25% in eligible candidates.

Despite lower success compared to IVF or ICSI, ROSI remains the only viable biological option for some men with complete spermatogenic failure.

Explore whether ROSI is worth trying in your specific case—book a session in Jeddah, Al Hofuf, or anywhere across KSA.

Is ROSI Safe and Ethical?

Since ROSI involves injecting a less-developed cell into an egg, questions about safety and long-term outcomes are common. Here’s what we know:

• ROSI has been used in Japan and Europe under research and clinical protocols.
• Studies have shown healthy pregnancies and live births, although data is still limited.
• Embryo development rates are lower than standard ICSI, but improving.
• All ROSI cases at VIVILITY are handled under strict ethical guidelines and informed consent.
• Patients are counseled extensively on risks, limitations, and alternatives.

We are proud to be among the few clinics in Saudi Arabia offering ROSI, with international best practices and a patient-first approach.

Talk to our fertility ethics board before proceeding with ROSI.

Why Choose VIVILITY for ROSI in Saudi Arabia?

At VIVILITY, we bring together expertise, innovation, and advanced lab infrastructure to offer solutions even when all other methods fail.

Here’s why patients choose us for ROSI:

• ROSI-trained embryologists and fertility specialists
• One of the few clinics in KSA offering spermatid-based fertilization
• In-house testicular biopsy and sperm analysis capabilities
• High safety and monitoring protocols for embryo development
• A compassionate, informed approach to rare fertility situations

Let us help you navigate this advanced path to fatherhood—book a ROSI assessment today.

Explore ROSI as Your Path to Fatherhood – Speak to a Specialist at VIVILITY in Saudi Arabia

If you’ve exhausted conventional fertility treatments and have been told there’s no chance due to complete sperm absence, don’t give up hope. ROSI may offer a way forward—and at VIVILITY, you’re in the hands of Saudi Arabia’s most trusted fertility experts.

Book your consultation in Riyadh, Jeddah, Dammam, Mecca, Medina, or your nearest city, and let us help you explore every possibility toward biological fatherhood.

You deserve a chance. Let’s create that chance—together.

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