Genetic Factors in Male Infertility – Testing & Treatment

Facing Repeated IVF Failure or Unexplained Infertility? Get Diagnosed in KSA

If you or your partner are struggling with repeated IVF failure, low or zero sperm count, or unexplained infertility in Saudi Arabia, genetic factors might be the hidden cause. At VIVILITY in KSA, we specialize in advanced genetic screening and personalized fertility treatments for men across Riyadh, Jeddah, Dammam, and beyond.

Our expert team helps you identify inherited or spontaneous mutations that impact fertility—and offers treatment plans tailored to your needs.

Book your confidential genetic screening today and take the first step toward clarity and solutions.

How Genetics Affect Male Fertility

Genetic disorders are a major yet often overlooked cause of male infertility. When the DNA within sperm cells is damaged or when there are chromosomal abnormalities, the body may produce low-quality sperm or none at all.

Key genetic infertility issues include:

• Sperm DNA fragmentation
• Y chromosome deletions
• Chromosomal translocations or mutations
• Gene defects inherited from one or both parents

These can affect sperm count, motility, morphology, and fertilization potential.

Early testing ensures the right treatment strategy and increases your chances of a successful pregnancy.

Common Genetic Conditions in Male Infertility

Several well-established genetic syndromes and mutations are linked to male infertility in Saudi Arabia:

• Klinefelter Syndrome: Affects 1 in 500-1,000 men. Males have an extra X chromosome (XXY), which impairs sperm production.
• Y Chromosome Microdeletions: Missing segments in the Y chromosome can lead to non-obstructive azoospermia or severe oligospermia.
• CFTR Gene Mutation: Common in men with congenital absence of vas deferens (a cause of obstructive azoospermia).
• Sertoli Cell-Only Syndrome: Testicles contain only supporting cells and no germ cells for sperm production.
• Chromosomal Translocations: Can lead to miscarriages or failed fertilization.

Suspect a genetic issue? Schedule a test with our fertility genetics experts in KSA.

When to Consider Genetic Testing for Infertility in KSA

You may be advised to undergo genetic testing if you experience:

• A very low or zero sperm count (azoospermia)
• Repeated IVF or ICSI failure
• A family history of infertility or miscarriage
• Consanguineous marriage (common in the region)
• Failed surgical sperm retrieval procedures (e.g., TESE, Micro-TESE)

Genetic testing offers clarity, prevents trial-and-error treatments, and provides vital information for family planning.

Types of Genetic Tests for Male Infertility

At VIVILITY KSA, we offer a full range of fertility-related genetic diagnostics:

• Y Chromosome Microdeletion Testing: Identifies missing regions related to sperm production
• Karyotyping: Checks for numerical or structural chromosomal abnormalities
• CFTR Mutation Screening: Especially for men with obstructive azoospermia
• Sperm DNA Fragmentation Test: Evaluates integrity of sperm DNA
• FISH Test (Fluorescent In Situ Hybridization): Detects chromosomal aneuploidies
• Genetic Counseling: Personalized assessment and planning with our specialists

Get your comprehensive male fertility test panel done by specialists in Riyadh or Jeddah.

How Genetic Testing Works at VIVILITY

The process is safe, confidential, and guided by fertility experts:

1. Initial Consultation & Medical History Review
2. Blood or Semen Sample Collection
3. Genetic Testing in Our Certified Lab
4. Expert Evaluation of Results
5. Follow-Up Counseling & Treatment Roadmap

Our patients receive detailed yet understandable results, along with recommendations for further action. Everything is handled with privacy and empathy.

Treatment Options for Genetic Male Infertility in KSA

While genetic infertility can’t always be reversed, we offer multiple effective solutions:

• ICSI (Intracytoplasmic Sperm Injection) using sperm from testicular extraction
• Sperm Retrieval Procedures like TESE, TESA, or Micro-TESE
• Donor Sperm Options in severe untreatable cases
• IVF with Preimplantation Genetic Testing (PGT) to select healthy embryos
• Hormonal Therapy (for treatable endocrine-related gene mutations)
• Sperm DNA Repair & Antioxidant Therapy (to reduce fragmentation)

We create a personalized fertility plan based on your genetic profile. Start with a free consultation.

Success Rates with Genetic Factor Treatments

Many couples in Saudi Arabia have achieved pregnancy even after being diagnosed with genetic infertility. Thanks to ART techniques like ICSI and IVF with genetic screening, success is no longer out of reach.

• ICSI success rate with testicular sperm: 40% to 60%
• Fertilization and pregnancy rates improve with tailored genetic counseling
• VIVILITY’s high-precision lab ensures optimal embryo selection and implantation support

Genetic Counseling for Male Infertility in KSA

Genetic counseling helps individuals and couples:

• Understand the nature of inherited infertility
• Make informed decisions about parenthood
• Plan treatment timelines and consider future risks

At VIVILITY, we support our patients throughout the entire journey—with compassion, data, and expert-led insights.

Get peace of mind by speaking to our certified fertility counselors in Saudi Arabia.

Book Your Genetic Screening Today

Don’t let uncertainty hold you back. At VIVILITY in KSA, we help men from Riyadh to Medina and Jazan to Tabuk discover the genetic root of infertility and overcome it with clarity and care.

Book your appointment today and begin your journey toward fatherhood with confidence.

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